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Preheat the broiler to 400° F. For easy cleanup, line a large, rimmed baking sheet with parchment paper.
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Slice the Italian loaf in half lengthwise and place on the baking sheet.
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On the bottom half of the bread, evenly layer and distribute all the deli meats.
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On the top half of the bread, evenly layer and distribute the cheese slices.
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Place the baking sheet in the oven and broil for 3-5 minutes or until the cheese has melted and the bread has become nice and crispy.
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Meanwhile, in a medium bowl, make the salad mixture by whisking the mayonnaise, Dijon mustard, red wine vinegar, pickle relish, and Italian seasoning together. Season to taste with a small pinch of salt and black pepper.
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Add red onion, and iceberg lettuce.
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Toss to combine.
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Remove the bread from the oven.
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Pile on the salad mixture, then top with tomato slices and grated parmesan cheese.
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Slice into 4 hearty sandwiches and enjoy!